Flupirtine Maleate Salt
Flupirtine Maleate
CAS: 75507-68-5
Molecular Formula: C19H21FN4O6
Flupirtine Maleate Salt - Names and Identifiers
| Name | Flupirtine Maleate |
| Synonyms | Keiton Ketadolon Flupirtine Maleate Flupirtine Maleate Salt Flupirtinemaleatelupirtine 2-AMino-6-[(p-fluorobenzyl)aMino]-3-pyridinecarbaMic Acid Ethyl Ester Maleate ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}carbamate (2Z)-but-2-enedioate 2-AMINO-6-[[(4-FLUOROPHENYL)METHYL]AMINO]-3-PYRIDINYL]-CARBAMIC ACID, ETHYL ESTER MALEATE N-[2-AMino-6-[[(4-fluorophenyl)Methyl]aMino]-3-pyridinyl]carbaMic Acid Ethyl Ester (2Z)-2-Butenedioate |
| CAS | 75507-68-5 |
| EINECS | 278-225-0 |
| InChI | InChI=1/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | DPYIXBFZUMCMJM-BTJKTKAUSA-N |
Flupirtine Maleate Salt - Physico-chemical Properties
| Molecular Formula | C19H21FN4O6 |
| Molar Mass | 420.3916432 |
| Melting Point | 186-188°C |
| Boling Point | 434.9°C at 760 mmHg |
| Flash Point | 216.8°C |
| Solubility | DMSO 84 mg/mL Water <1 mg/mL Ethanol 3 mg/mL |
| Vapor Presure | 9.1E-08mmHg at 25°C |
| Appearance | solid |
| Color | white |
| Maximum wavelength(λmax) | ['343nm(CH3CN)(lit.)'] |
| Merck | 14,4190 |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| MDL | MFCD00941415 |
| In vitro study | Flupirtine blocks NMDA and gp120 HIV-1-induced cell death in rat cortical neurons. When the concentration of Flupirtine is 1-10 mM, it protects the primary nerve cells from the toxicity induced by sodium glutamate by reducing the concentration of calcium ions. At concentrations of 1 or 5 μg/mL, Flupirtine acts on primary neuronal cells and blocks apoptosis induced by β-amyloid (25-35). Flupirtine at a concentration of 10 μm significantly reduced Non-receptor-regulated necrotic cell death in PC 12 cultures treated with 10 mM L-glutamate, while Flupirtine acted on PC 12 cultures, has an antioxidant effect. Decreased TRAIL-regulated human live brain tissue culture death at Flupirtine concentrations of 1 μm and 10 μm. Flupirtine activates inwardly rectifying potassium channels, thereby stabilizing the resting membrane potential at therapeutically relevant concentrations. |
| In vivo study | Flupirtine has a protective effect on hippocampal and striatal neuronal injury. In animal studies, Flupirtine concentrates on treatment, inhibiting neuropathic pain responses induced by chemical, thermal, mechanical, and electrical stimuli. Flupirtine acts on rats and has a muscle-relaxing effect. |
Flupirtine Maleate Salt - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S35 - This material and its container must be disposed of in a safe way. S20 - When using, do not eat or drink. |
| WGK Germany | 3 |
| RTECS | EY8555800 |
| HS Code | 29333990 |
Flupirtine Maleate Salt - Introduction
Flupirtine maleate salt
Last Update：2022-10-16 17:28:26
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